8,9 This Letter does not discuss controversy over IV iron use for hemodialysis patients. When iron repletion is urgent, IV administration saves time, blood transfusion, and money and is underutilized.
Examples include heavy menses, celiac disease, gastric bypass, inflammatory bowel disease, and GI bleeding. However, sometimes iron must be given parenterally. IV iron can rescue patients unable to tolerate or absorb oral iron, or who lose blood rapidly. Treatment with oral iron and/or diet is usually simple, although only a tiny fraction of ingested elemental iron is absorbed. 3,4,5 Identifying the cause is always important. hair loss, nail and mucosal changes), but there is surprisingly little evidence about whether treatment is beneficial. fatigue, impaired concentration, weakness) and signs (e.g. Deficiency without anemia may cause non-specific symptoms (e.g. Iron is essential for oxygen transport by hemoglobin (Hb), but also for energy metabolism, including the mitochondrial electron transport chain.
2 This estimate is probably low, as the ferritin cutoff is arbitrary and it excludes residents of First Nation reserves, where nutrition is often inferior to the rest of Canada. 1 In Canada (2009-11), deficiency defined as serum ferritin < 15 mcg/L was estimated to affect 13% of females aged 12-19, and 9% of females aged 20-49. Anemia affects about one-third of humans iron (Fe) deficiency is the most common cause.
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